BCLA CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye

This paper outlines changes to the ocular surface caused by contact lenses and their degree of clinical significance. Substantial research and development to improve oxygen permeability of rigid and soft contact lenses has meant that in many countries the issues caused by hypoxia to the ocular surface have largely been negated. The ability of contact lenses to change the axial growth characteristics of the globe is being utilised to help reduce the myopia pandemic and several studies and meta-analyses have shown that wearing orthokeratology lenses or soft multifocal contact lenses can reduce axial length growth (and hence myopia).However, effects on blinking, ptosis, the function of Meibomian glands, fluorescein and lissamine green staining of the conjunctiva and cornea, production of lid-parallel conjunctival folds and lid wiper epitheliopathy have received less research attention. Contact lens wear produces a subclinical inflammatory response manifested by increases in the number of dendritiform cells in the conjunctiva, cornea and limbus. Papillary conjunctivitis is also a complication of all types of contact lenses. Changes to wear schedule (daily disposable from overnight wear) or lens materials (hydrogel from SiHy) can reduce papillary conjunctivitis, but the effect of such changes on dendritic cell migration needs further study. These changes may be associated with decreased comfort but confirmatory studies are needed. Contact lenses can affect the sensitivity of the ocular surface to mechanical stimulation, but whether these changes affect comfort requires further investigation.In conclusion, there have been changes to lens materials, design and wear schedules over the past 20+ years that have improved their safety and seen the development of lenses that can reduce the myopia development. However, several changes to the ocular surface still occur and warrant further research effort in order to optimise the lens wearing experience.     

浅议生态环境监测机构的风险控制

现阶段,为了探索创新性的发展途径,生态环境监测机构应始终增强风险控制意识。应加强风险管理,立足于风险控制,以求不断健康发展。     

Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy

Since researchers began studying the mechanism of flavonoids’ anticancer activity, little attention has been focused on the modulation of redox state in cells as a potential chemotherapeutic strategy. However, recent studies have begun identifying that the anticancer effect of flavonoids occurs both in their antioxidative activity which scavenges ROS and their prooxidative activity which generates ROS. Against this backdrop, this study attempts to achieve a comprehensive analysis of the individual and separate study findings regarding flavonoids’ modulation of redox state in cancer cells. It focuses on the mechanism behind the anticancer effect, and mostly on the modulation of redox potential by flavonoids such as quercetin, hesperetin, apigenin, genistein, epigallocatechin-3-gallate (EGCG), luteolin and kaempferol in both in vitro and animal models. In addition, the clinical applications of and bioavailability of flavonoids were reviewed to help build a treatment strategy based on flavonoids’ prooxidative potential.     

新型地锚张弦梁式泥石流格栅坝构件受力的简化计算方法

针对常见泥石流防治结构被冲击破坏的问题，基于“柔性消能”理念，结合张弦梁结构和竖向预应力锚杆技术，提出一种既能改善结构受力性能、增加结构整体抗冲击能力、保证结构安全可靠，又能减小结构构件截面尺寸、节约成本、便于现场施工组装和后期运营维护的新型地锚张弦梁式泥石流格栅坝，并阐述其技术原理。根据泥石流荷载分布和新型地锚张弦梁式泥石流格栅坝的受力特征，给出其简化的内力计算方法；并利用SAP2000建立新结构有限元模型，分析了结构的整体受力，验证了构件简化计算方法的合理性；结合Python语言和Qt De? signer软件开发了相应的设计计算软件，对新型地锚张弦梁式泥石流格栅坝的内力进行求解。结果表明：提出的新结构抗冲击性能好，构件受力均匀；以后设计中应关注竖杆的剪切脆性破坏和立柱偏心受力情况，保证结构安全；变形协调仅使底层张弦梁与竖杆内力偏大，实际工程应用时，应着重验算底层构件，防止其破坏；文中提出的简化计算方法能较准确的反映结构的受力特性，具有一定的合理性，研究可为新型地锚张弦梁式泥石流格栅坝的设计计算和推广应用提供理论依据和技术支持。     

基于参数预标定的长行程PMLSM无传感器控制

为了解决长行程定子不连续永磁直线同步电机存在的因无法全程安装位置传感器和不同动子和定子之间的电磁参数不固定所造成的控制性能下降的难题,提出一种在每一段定子内先进行参数标定,再进行速度控制的控制系统设计。首先,在动子进入过程中,对电机进行电磁参数标定,根据标定参数对控制器参数进行调整,以达到更好的控制效果。然后,使用无位置传感器控制系统使动子快速达到设定速度值并稳定运行。实验结果表明:动子进入过程参数标定精度分别为0.002Wb和0.000 4H;无位置传感器控制中位置估计精度为0.63mm,速度收敛时间为0.45s,稳态误差为0.02m/s。基本满足永磁直线同步电机用于长行程运输的控制快速性、稳定性等要求。     

Strain rate dependence of the contribution of surface diffusion to bulk sintering viscosity

Modeling of bulk sintering viscosity usually neglects the contribution of pore surface diffusion with respect to grain-boundary diffusion. This approximation is questionable at the high densification rates used today in advanced fast sintering techniques. A two-dimensional analysis of the problem shows that the influence of surface diffusion on bulk viscosity at high strain rate can be decomposed as the sum of two terms: a term linked to the change in pore surface curvature and a term linked to the change in grain-boundary size. The computational procedure relies on the partition of pore profile evolution into a transient component accounting for non-densifying phenomena and an asymptotic component accounting for strain-rate-controlled phenomena. The largest impact of surface diffusion is found to arise from the change in grain-boundary size. It follows a transition from Newtonian viscosity at low strain rate to non-Newtonian viscosity which, during densification, increases nearly linearly with strain rate. In some conditions, viscosity can then reach more than twice the value estimated when neglecting pore surface diffusion. Reversely, expansion is accompanied by a decrease in grain-boundary size which causes a decrease in viscosity and can lead to grain separation at high strain rate.     

Passivity‐based adaptive control of a 2‐DOF serial robot manipulator with temperature dependent joint frictions

Mechanical systems are always suffering from the effects of temperature dependent friction forces where the system is operated in a wide range of temperature. Temperature and its variation play an important role in friction force in mechanical systems. If it is not compensated, it will tend to unwanted consequences, including steady‐state errors, limit cycling, and hunting. Therefore, it is necessary to take the temperature effects into account. This has been a strong motivation for the researchers to work on temperature effects on joint friction. In this paper, an adaptive compensation (control) scheme is proposed and applied to a 2‐degree‐of‐freedom serial robot manipulator by taking the temperature effects into account on the joints friction. In the proposed control scheme, the temperature is not required to be sensed. In this paper, joint friction is described by LuGre dynamic model with temperature dependent parameters. These parameters are described by some functions with unknown temperature dependent terms. According to the mathematical and practical concepts, the temperature dependent friction is decomposed into a viscous term and a disturbance term. An adaptive controller is designed to compensate the friction effect and it is shown that the proposed controller relaxes the condition for a priori knowledge about the environment characteristics, including the upper and lower bounds of the environment temperature and the parameters of the functions, describing the temperature dependent joint frictions. The stability and convergence of the joint position and velocity are proved in the sense of Lyapunov and then the proposed method is confirmed by the simulations.     

Novel model reference adaptive control architecture using semi‐initial excitation‐based switched parameter estimator

This paper is a generalization of the recently developed techniques of initial excitation (IE)–based adaptive control with an introduction to the definition of semi‐initial excitation (semi‐IE), a still more relaxed notion than IE. Classical adaptive controllers typically ensure Lyapunov stability of the extended error dynamics (tracking error + parameter estimation error) and asymptotic tracking, while requiring a stringent condition of persistence of excitation (PE) for parameter convergence. Of late, the authors have proposed a new adaptive control architecture, which guarantees parameter convergence under the online‐verifiable IE condition leading to exponential stability of the extended error dynamics. In earlier works, it has been established that the IE condition is significantly milder than the classical PE condition. The current work further slackens the excitation condition by proposing the concept of semi‐IE. The proposed adaptive controller is proved to ensure convergence of the parameter estimation error to a lower‐dimensional manifold under the weaker semi‐IE condition, while the stronger condition of IE guarantees convergence of the parameter estimation error to zero. The designed algorithm is shown to improve transient response of tracking error sufficiently in contrast to conventional adaptive controllers.     

环境监测的现状、发展及优化对策浅析

社会经济的快速发展对生态环境造成了较大破坏,并产生了一系列连锁反应,不利于我国可持续发展目标的实现。为此,必须要切实做好环境监测工作。本文从环境监测的概念出发,就现阶段的环境监测现状进行了分析,并在此基础上阐述了环境监测工作未来发展及优化对策,以供参考。     

Adaptive constraint control for flexible manipulator systems modeled by partial differential equations with dead-zone input

In this article, based on partial differential equations (PDEs), the flexible manipulator system with both dead-zone input and state constraints is studied. The dynamic model of the flexible manipulator system is described by PDEs. The parameters of the dead-zone input are unknown, and the state constraint problem is also considered. An adaptive approach is proposed to offset the effects caused by dead-zone input. Thus, to guarantee that all states remain within their respective constraint regions, the boundary control law based on the barrier Lyapunov function is given, and an adaptive controller is designed. According to the Lyapunov analysis method, the control method is given to ensure that all signals of the closed-loop system are bounded and all states satisfy the constraint conditions. Finally, simulation results show the effectiveness of the proposed control method in this article.